Encapsulation of Lavandula austroapennina N.G. Passal., Tundis & Upson extracts: Focus on leaf and stem enriched liposome for cosmeceutical innovation

In the framework aimed at valorizing Lavandula austroapennina N.G. Passal., Tundis & Upson, an endemic species of the Apennine mountains of southern Italy, through the deep investigation of its organ chemical composition and bioactivity, innovative cosmeceutical applications are of interest. Thus, lipophilic and alcoholic extracts, at dose levels avoiding cytotoxicity in keratinocytes, were encapsulated into liposomes by applying thin-film hydration method. This was aimed to overcome known plant extract issues, such as poor solubility, high instability, and low skin permeation. The lipid-based vesicles were characterized by particle size dimension ≤300 nm, negative charge (-8 to −20 mV) and polydispersity index