A novel pH-responsive charge reversal nanospheres based on acetylated histidine-modified lignin for drug delivery

A novel pH-responsive charge reversal nanospheres based on acetylated histidine-modified lignin for drug delivery

In this work, we developed a novel technique to prepare pH-responsive charge reversal nanospheres based on softwood kraft lignin (SKL) through two steps modification and high efficient self-assembly. SKL was first grafted with imidazole groups by Mannich reaction and further fabricated into acetylat...

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Veröffentlicht in:Industrial crops and products 2022-10, Vol.186, p.115193, Article 115193
Hauptverfasser: Yi, Conghua, Xu, Qinghe, Yang, Dongjie, Wang, Miao
Format: Artikel
Sprache:eng
Schlagworte:
Charge reversal
Controlled release
Drug delivery
Lignin nanosphere
PH-responsive
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Zusammenfassung:In this work, we developed a novel technique to prepare pH-responsive charge reversal nanospheres based on softwood kraft lignin (SKL) through two steps modification and high efficient self-assembly. SKL was first grafted with imidazole groups by Mannich reaction and further fabricated into acetylated histidine-modified lignin (Ace-SKL-HIS) via acetylation reaction. Ace-SKL-HIS nanospheres (Ace-SKL-HIS NPs) were prepared by fast vacuum evaporation method, their effective diameters (ED) were around 100 nm, exhibited low Polydispersity Index(PDI,
ISSN:0926-6690
1872-633X
DOI:10.1016/j.indcrop.2022.115193