Avermectin loaded carboxymethyl cellulose nanoparticles with stimuli-responsive and controlled release properties
Flow chart for the preparation of avermectin nanoparticles with stimuli-responsive and controlled release by self-assembly technology. [Display omitted] •Esterase-responsive avermectin nanoparticles was prepared through self-assembly.•It has good wetting properties and resistance to photodegradation...
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Veröffentlicht in: | Industrial crops and products 2020-09, Vol.152, p.112497, Article 112497 |
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Sprache: | eng |
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Zusammenfassung: | Flow chart for the preparation of avermectin nanoparticles with stimuli-responsive and controlled release by self-assembly technology.
[Display omitted]
•Esterase-responsive avermectin nanoparticles was prepared through self-assembly.•It has good wetting properties and resistance to photodegradation.•It is a green and efficient pesticide controlled release formulation.
Polyethylene glycol (PEG) was introduced into carboxymethyl cellulose (CMC) to form hydrophilic chain of PEG-CMC. Avermectin (Avm) was grafted on the long chain of PEG-CMC by use of N, N-dicyclohexylcarbodiimide (DCC) as the dehydrant and 4-dimethylaminopyridine (DMAP) as the catalyst to form the amphiphilic molecule. Then the avermectin nanoparticles was prepared with esterase-responsive sustained release successfully through self-assembly. The size of nanoparticles was less than 400 nm. Avermectin loading was 8% and the degradation rate was less than 50 % under the xenon arc lamp for 72 h. Compared with avermectin technical, it showed an obvious anti-photodegradation advantage. Compared with commercially available water-dispersible granules (WDG), the avermectin nanoparticles had a smaller contact angle on the cucumber leaf surface and there was a significant difference. The toxicity test showed that the nanoparticles have a certain insecticidal effect on the larva of Hyphantria cunea and the sensitivity increased gradually over time. |
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ISSN: | 0926-6690 1872-633X |
DOI: | 10.1016/j.indcrop.2020.112497 |