Miscibility, phase behavior, and mechanical properties of copovidone/HPMC ASLF and copovidone/Eudragit EPO polymer blends for hot-melt extrusion and 3D printing applications

[Display omitted] Currently, most amorphous solid dispersion (ASD) formulations contain a single polymer to stabilize an amorphous drug. However, a single polymer has a limited ability to form strong drug-polymer interactions, resulting in poor drug loading (400 MPa), high flexural stress (>400 MPa), high flexural modulus (>200 MPa), and adequate flexural strain (≥2 %). These characteristics make the Copovidone/HPMC ASLF filament particularly suitable for 3D printing applications, outperforming the Copovidone/Eudragit EPO filament. Overall, this study presents a multi-scale investigation to assess the polymer blend miscibility. It also highlights the potential of the Copovidone/HPMC ASLF blend for ASD formulations and FDM based 3D printing applications in pharmaceutical development.