Design of dye and superparamagnetic iron oxide nanoparticle loaded lipid nanocapsules with dual detectability in vitro and in vivo

[Display omitted] Lipid nanocapsules are treasured nanoparticulate systems, although they lack detectability in biological environments. To overcome this, we designed LNCs loaded simultaneously with fluorescent dye and superparamagnetic iron oxide nanoparticles (Dual LNCs). The introduction of both...

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Veröffentlicht in:	International journal of pharmaceutics 2020-07, Vol.585, p.119433, Article 119433
Hauptverfasser:	Bohley, Marilena S., Birch, Emily, Baumann, Felix J., Dillinger, Andrea E., Tamm, Ernst R., Goepferich, Achim M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemistry, Pharmaceutical - methods Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Compounding Drug Liberation Drug Stability Endothelial Cells - drug effects Female Fluorescence microscopy Fluorescent Dyes - administration & dosage Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacokinetics Humans ICP-OES Lipid nanocapsules Lipids - chemistry Magnetic Iron Oxide Nanoparticles - chemistry Mice Mice, 129 Strain Microscopy, Energy-Filtering Transmission Electron Microscopy, Fluorescence Nanocapsules - chemistry Particle Size SPIONs TEM
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Zusammenfassung:	[Display omitted] Lipid nanocapsules are treasured nanoparticulate systems, although they lack detectability in biological environments. To overcome this, we designed LNCs loaded simultaneously with fluorescent dye and superparamagnetic iron oxide nanoparticles (Dual LNCs). The introduction of both labels did not alter nanoparticle characteristics such as size (50 nm), size distribution (polydispersity index
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2020.119433