Effects of nano-curcumin supplementation on oxidative stress, systemic inflammation, adiponectin, and NF-κB in patients with metabolic syndrome: A randomized, double-blind clinical trial

Oxidative stress and inflammation are known to play a central pathophysiological role in the development and clinical expression of metabolic syndrome (MetS). Curcumin, a yellow polyphenolic compound extracted from turmeric, has been found to have antioxidant and anti-inflammatory activities. The present study aimed to evaluate the effects of nano-micelle curcumin on oxidative stress, systemic inflammation, adiponectin, and nuclear factor-κB (NF-κB) in patients with MetS. In this randomized, double-blind, clinical trial, 50 patients with metabolic syndrome were randomly assigned into the nano-micelle curcumin and the placebo groups to receive either 80 mg/day nano-curcumin or placebo for 12 weeks. The mean malondialdehyde (MDA) level decreased in the nano-micelle curcumin group compared to the baseline (8.07 ± 3.14 vs. 6.39 ± 2.11; p