Exploration of the diagnostic value and expression levels of blood IFN-γ and IL-2 in patients with lymph node tuberculosis

Symptoms and signs of lymph node tuberculosis(LNTB) lack specificity, which making identification difficult and increasing the likelihood of missed or misdiagnosed cases.This study aimed to examine the diagnostic effectiveness of IFN-γ/IL-2,for differentiating LNTB from non-tuberculous lymphadenopat...

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Veröffentlicht in:Heliyon 2024-10, p.e39008, Article e39008
Hauptverfasser: Zhang, Hao, Chen, Yu, Huang, Jun, Hang, Tianxing, Huang, Lili, Gao, Jianqi, Yin, Guoping, Hu, Chunmei
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Sprache:eng
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Zusammenfassung:Symptoms and signs of lymph node tuberculosis(LNTB) lack specificity, which making identification difficult and increasing the likelihood of missed or misdiagnosed cases.This study aimed to examine the diagnostic effectiveness of IFN-γ/IL-2,for differentiating LNTB from non-tuberculous lymphadenopathy(Non-TB-LAP) , as well as to analyze the variations in their expression levels among different subgroups. Ultimately, 95 patients with enlarged lymph nodes were enrolled in the study. Based on the diagnostic criteria of LNTB, 38 patients were Confirmed LNTB, 28 patients were Clinically diagnosed LNTB and 29 patients were Non-TB-LAP. The cut-off values of IFN-γ/IL-2 for differentiating LNTB from Non-TB-LAP were 58.267 pg/mL and 12.207 pg/mL respectively, through receiver operating characteristic curves. In patients with LNTB and Non-TB-LAP, the sensitivity of IFN-γ/IL-2 in parallel was 83.08%, which was higher than that of IFN-γ(p
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e39008