Association of APOA1 gene polymorphisms (G-75A and C+83T) with deep vein -thrombosis: An Indian study

High density lipoprotein modulates the expression profile of various coagulation factors and helps in prevention of many diseases through its main protein content ApoA1 which is anti-thrombotic, anti-inflammatory and anti-oxidative in nature. Several polymorphisms have been found in the APOA1 gene but only rs670 (G-75A) and rs5069 (C+83T) have been studied extensively in various diseased condition but heterogeneous association has been observed. Association of these two polymorphisms has not been established in deep vein thrombosis so far. Attempt has been made to bridge this gap and establish the risk assessment of these two polymorphisms on the cardiovascular risks by meta-analysis which was further validated in thrombosis patients' samples along with healthy subjects. Total 2363, relevant studies received in initial search by various sources and using inclusion and exclusion criteria only 12 studies were taken for analysis. Combined OR with 95% CI calculated for all genetic model shows absence of noteworthy association between polymorphisms and cardiovascular disease risks however significant heterogeneity (I2 > 50%) was observed in all models. Egger's & Begg's test values along with funnel plot shows absence of publication bias in the meta-analysis. For validation, distribution of G-75A and C+83T polymorphism in thrombosis patients and healthy subjects were analyzed. Genotypic and allelic frequencies for both polymorphisms were assessed in all genetic models and frail association was found in all models. Results depict that there was absence of these two polymorphisms in thrombosis patient and healthy subjects and there could be some other polymorphism which play pivotal role in diseases pathogenesis. •APOA1 gene polymorphisms (G-75A and C+83T) for CVD: meta-analysis•Validation in thrombosis patients and healthy subjects: Indian population•Association of G-75A and C+83T with thrombosis incidents is extraneous.