The in silico evaluation of microbial community of gastric microbiota and their role in dyspepsia in two populations from southwestern in Colombia

Gastric cancer is one of the most important solid tumors, and is usually associated with high mortality rates. There are several factors involved in the development of gastric cancer, among which, Helicobacter pylori is one of the most important etiological ones. However, the reason for the difference in the incidence of gastric cancer in areas with similar colonization rates of Helicobacter pylori remains a mystery. In the present study, gastric microbiota of 6 patients living in the two areas of Túquerres and Tumaco were evaluated to identify the microbial diversity of antral biopsies in these two communities. We found that the microbial diversity of gastric microbiota was very high in the populations of Túquerres and Tumaco, and that only Fusobacterium and Bacteroides were present in two populations; 27 operational taxonomic units (OTUs) showed a significant difference between the two populations, and mainly microbial diversity in the Tumaco population was particularly higher in intestinal metaplasia than in the inhabitants of Tuquerres. Microbial diversity appears to protect against developing gastric cancer by affecting host metabolism, inhibiting persistent colonization of H. pylori, and responding to the immune system. We need to conduct further studies due to the limitations of current studies. •There are limit finding about effect of gastric microbiota and its community diversity during dyspepsia.•In this in silico study, we compared gastric microbiota of dyspeptic patients from two populatios from southwestern in Colombia with 25-fold difference in gastric cancer.