Screening of different lamellar solids for the adsorption of phenolic compounds from grape pomace

Grape pomace (GP) is recognized as a valuable source of polyphenols, prompting research into new therapeutic molecules while enhancing this by-product value. To address low stability and bioavailability issues of phenolic compounds, lamellar solids emerge as a promising approach for their loading and stabilization in food, cosmetic, and pharmaceutical applications. A solid phase adsorption procedure was developed here by comparing the properties of eight solids towards GP polyphenols. Magnesium aluminium azelate showed nearly complete adsorption and low release. The adsorption/desorption ability of the selected supports was monitored by HPLC-DAD and spectrophotometry assays. The chemometric approach, based on Principal Component Analysis and k-means clustering, identified three distinct clusters based on solid properties. Additionally, color analysis revealed similarities between residues treated with magnesium aluminium chloride and carbonate. The comprehensive analytical methodology employed for the adsorption/retention of GP polyphenols in lamellar solids is presented herein for the first time. [Display omitted] •Lamellar solids as an approach for adsorption/retention of grape pomace polyphenols.•In vitro antioxidant activity of the residual solutions remaining after adsorption.•HPLC-PDA analyses to monitor the adsorption of polyphenols on the inorganic solids.•Chemometric analysis for clustering of solids based on similar adsorption properties.•Color change upon extract adsorption underlying the influence of bioactives nature.