A laboratory study on dissipation and risk assessment of the proinsecticide thiocyclam and its metabolite nereistoxin in tomato using liquid chromatography high resolution mass spectrometry

•Dissipation kinetics of thiocyclam were evaluated in tomato using LC-HRMS.•Nereistoxin, a thiocyclam metabolite, was more persistent (>60 days)•Four nereistoxin metabolites were also detected in samples.•Nereistoxin should be monitored in routine laboratories rather than thiocyclam.•More nereistoxin toxicity data are necessary to perform proper risk assessment. Reduced pesticides use, alongside increased organic farming, has created a need for new biological products, such as thiocyclam, to control pests. Thiocyclam has scarcely been studied, making the study of its degradation in fruits and vegetables, such as tomatoes, an urgent requirement. To monitor thiocyclam metabolites in tomato, dissipation studies were carried out using a liquid chromatography-Orbitrap mass spectrometry (UHPLC-Orbitrap MS) method for 60-days after foliar application. Thiocyclam was not persistent (DT50 60 days. Four nereistoxin metabolites, detected at low concentrations (