Four undescribed sesquiterpenes from Artemisia mongolica and their anti-inflammatory activity

Four undescribed sesquiterpene compounds (1–4) and six known compounds (5–10) were isolated from A. mongolica. Furthermore, compound 5 was a new natural product previously synthesized. The LPS-stimulated BV2 cells were used as a model to evaluate the anti-inflammatory activity of the isolated compou...

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Veröffentlicht in:	Fitoterapia 2024-09, Vol.177, p.106093, Article 106093
Hauptverfasser:	Wang, Fangsheng, Wen, Huizhen, He, Fei, Li, Jun, Aisa, Haji Akber, Xin, Xuelei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Artemisia - chemistry Artemisia mongolica BV2 Cell Line China Mice Molecular Structure Nitric Oxide - metabolism Phytochemicals - isolation & purification Phytochemicals - pharmacology Sesquiterpenes Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
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Zusammenfassung:	Four undescribed sesquiterpene compounds (1–4) and six known compounds (5–10) were isolated from A. mongolica. Furthermore, compound 5 was a new natural product previously synthesized. The LPS-stimulated BV2 cells were used as a model to evaluate the anti-inflammatory activity of the isolated compounds, among them, compounds 2, 3 and 4 showed significant inhibition of NO levels with IC50 values of 27.48, 27.39 and 24.96 μM, respectively. [Display omitted]
ISSN:	0367-326X 1873-6971
DOI:	10.1016/j.fitote.2024.106093