Chemical composition, antioxidant, and anti-diabetic activities of ethyl acetate fraction of Stachys riederi var. japonica (Miq.) in streptozotocin-induced type 2 diabetic mice

Chemical composition, antioxidant, and anti-diabetic activities of ethyl acetate fraction of Stachys riederi var. japonica (Miq.) in streptozotocin-induced type 2 diabetic mice

This work analysed the chemical composition, antioxidant, and enzyme inhibitory activities of solvent extract (SJ-ME) and fractions (SJ-HF, SJ-EAF, and SJ-MF) of the Stachys riederi var. japonica (Miq.) (SJ). Furthermore, the effect of SJ-EAF in STZ induced type 2 diabetic mice was examined. Among t...

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Veröffentlicht in:Food and chemical toxicology 2021-09, Vol.155, p.112374, Article 112374
Hauptverfasser: Saravanakumar, Kandasamy, Park, SeonJu, Mariadoss, Arokia Vijaya Anand, Sathiyaseelan, Anbazhagan, Veeraraghavan, Vishnu Priya, Kim, SeongJung, Wang, Myeong-Hyeon
Format: Artikel
Sprache:eng
Schlagworte:
alpha-Amylases - metabolism
alpha-Glucosidases - metabolism
Animals
Antioxidant
Antioxidants - chemistry
Antioxidants - metabolism
Antioxidants - therapeutic use
Antioxidants - toxicity
Cell Line, Tumor
Chemical composition
Diabetes
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Diabetes Mellitus, Type 2 - chemically induced
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Gene Expression - drug effects
Humans
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - metabolism
Hypoglycemic Agents - therapeutic use
Hypoglycemic Agents - toxicity
LC-MS/MS
Male
Mice
Mice, Inbred ICR
Molecular Docking Simulation
Plant Extracts - chemistry
Plant Extracts - metabolism
Plant Extracts - therapeutic use
Plant Extracts - toxicity
Protein Binding
Stachys - chemistry
Stachys riederi var. japonica (Miq.)
Streptozocin
Streptozotocin
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Zusammenfassung:This work analysed the chemical composition, antioxidant, and enzyme inhibitory activities of solvent extract (SJ-ME) and fractions (SJ-HF, SJ-EAF, and SJ-MF) of the Stachys riederi var. japonica (Miq.) (SJ). Furthermore, the effect of SJ-EAF in STZ induced type 2 diabetic mice was examined. Among the samples, SJ-EAF exhibited a lower IC50 concentration of 64.2 ± 0.48 μg/mL for DPPH and 82.6 ± 0.09 μg/mL for ABTS+. The SJ-EAF concentration of 2.89 ± 0.03 μg and 2.27 ± 0.98 μg was equivalent to 1 μg of acarbose mediated enzyme inhibitory effect against α-amylase and α -glucosidase, respectively. The SJ-EAF did not show cytotoxicity (
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2021.112374