Immunotoxicology of cadmium: Cells of the immune system as targets and effectors of cadmium toxicity

Cadmium (Cd) has been listed as one of the most toxic substances affecting numerous tissues/organs, including the immune system. Due to variations in studies examining Cd effects on the immune system (exposure regime, experimental systems, immune endpoint measured), data on Cd immunotoxicity in humans and experimental animals are inconsistent. However, it is clear that Cd can affect cells of the immune system and can modulate some immune responses. Due to the complex nature of the immune system and its activities which are determined by multiple interactions, the underlying mechanisms involved in the immunotoxicity of this metal are still vague. Here, the current knowledge regarding the interaction of Cd with cells of the immune system, which may affect immune responses as well as potential mechanisms of consequent biological effects of such activities, is reviewed. Tissue injury caused by Cd-induced effects on innate cell activities depicts components of the immune system as mediators/effectors of Cd tissue toxicity. Cd-induced immune alterations, which may compromise host defense against pathogenic microorganisms and homeostatic reparative activities, stress this metal as an important health hazard. [Display omitted] •The complex structure of the immune system makes it a sensitive cadmium (Cd) target.•Cd-induced neutrophil inflammatory activities are responsible for tissue injury.•Cd can exert both stimulation and inhibition of mononuclear phagocytes.•Cd alters lymphocyte development.•Cd-induced alteration of cellular immune reactions increases susceptibility to pathogens.