RIFM fragrance ingredient safety assessment, caryophyllene oxide, CAS Registry Number 1139-30-6

•Caryophyllene oxide; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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Bibliographische Detailangaben
Veröffentlicht in:	Food and chemical toxicology 2020-04, Vol.138, p.111102, Article 111102
Hauptverfasser:	Api, A.M., Belmonte, F., Belsito, D., Biserta, S., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Gadhia, S., Jones, L., Joshi, K., Lapczynski, A., Lavelle, M., Liebler, D.C., Na, M., O'Brien, D., Patel, A., Penning, T.M., Ritacco, G., Rodriguez-Ropero, F., Romine, J., Sadekar, N., Salvito, D., Schultz, T.W., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., Tsang, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria - drug effects Ecotoxicology Endpoint Determination Environmental safety Genotoxicity Humans Local respiratory toxicity No-Observed-Adverse-Effect Level Odorants Perfume - chemistry Perfume - toxicity Phototoxicity/photoallergenicity Polycyclic Sesquiterpenes - chemistry Polycyclic Sesquiterpenes - toxicity Repeated dose, developmental, and reproductive toxicity Risk Assessment Skin sensitization
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Beschreibung
Zusammenfassung:	•Caryophyllene oxide; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.
ISSN:	0278-6915 1873-6351
DOI:	10.1016/j.fct.2019.111102