Screening, identification, and mechanistic exploration of DPP-IV inhibitory peptides from collagen in Esox lucius skin

Screening, identification, and mechanistic exploration of DPP-IV inhibitory peptides from collagen in Esox lucius skin

Food-derived dipeptidyl peptidase IV (DPP-IV) inhibitors show promise as a therapeutic intervention for type 2 diabetic mellitus (T2DM). This investigation used a combination of virtual screening and enzymatic digestion to prepare and identify novel DPP-IV inhibitory peptides from Esox lucius, a typ...

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Veröffentlicht in:Food bioscience 2025-01, Vol.63, p.105698, Article 105698
Hauptverfasser: Li, Jialu, Wei, Yabo, Lei, Yongdong, Guo, Xin, Zhao, Yindi, Hao, Qi, Xiaorong Deng, Zhang, Jian
Format: Artikel
Sprache:eng
Schlagworte:
DPP-IV inhibitory peptide
Esox lucius
Molecular docking
Virtual screening
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Zusammenfassung:Food-derived dipeptidyl peptidase IV (DPP-IV) inhibitors show promise as a therapeutic intervention for type 2 diabetic mellitus (T2DM). This investigation used a combination of virtual screening and enzymatic digestion to prepare and identify novel DPP-IV inhibitory peptides from Esox lucius, a typical cold-water fish from Xinjiang. Alkaline protease digest showed the best inhibitory effect of 62.04% ± 1.07%. The ultrafiltration U1 (
ISSN:2212-4292
DOI:10.1016/j.fbio.2024.105698