Characterization of lipid systems based on fully hydrogenated soybean and high oleic sunflower oils to obtain nanostructured lipid carriers

Resistance to chemical degradation, a melting point above body temperature, biodegradability, and generally regarded as safe status are prerequisites for a lipid matrix to produce nanostructured lipid carriers (NLC). This study aimed to evaluate the composition and physical and crystallization properties of lipid systems composed of fully hydrogenated soybean oil (FHSO) and high oleic sunflower oil (HOSO). The lipid systems were characterized by their composition in fatty acids and triacylglycerol (TAG), thermal behavior during melting and crystallization, solid fat content (SFC), microscopical features, and polymorphism. Elevated HOSO in lipid systems promoted an increase in unsaturated fatty acids (UFA) and di- and tri-unsaturated TAG, a reduction in SFC and in crystalized areas and variations in thermal behavior. Excepted lipid system 10:90 FHSO:HOSO (w/w), all systems exhibited polymorphic stabilization in β form after 60 days. Findings of the present study demonstrated that the raw materials are compatible for the formulation of NLC.