Chemical characterization of p-hydroxycinnamic diesters extracted from Copernicia prunifera and attenuation of biomarkers in C57BL/6J diabetic mice

p-Hydroxycinnamic diester is very common in fruits and beverages. Furthermore, it belongs to the family of cinnamic acids. It is a chemical compound present in carnauba leaf powder, and it has promising pharmacological properties against non-transmissible chronic diseases. Then, the objective of this work was characterizing the chemical composition of p-hydroxycinnamic diester obtained from carnauba leaf powder, as thoroughly evaluate its antioxidant profile and to analyze its effect in diabetic mice induced by high-fat diet. Male C57BL/6J mice were induced by 60 days by a high-fat diet and treated for 30 days with p-hydroxycinnamic diester (200 e 400 mg/Kg) and metformin (200 mg/Kg). p-Hydroxycinnamic diester presented chemical structure consistent with the cinnamic acid derivatives reported in scientific literature. Furthermore, p-hydroxycinnamic diester exhibited excellent in vivo and in vitro antioxidant activity, and it also decreased glycemia, MDA, reactive oxygen species in liver tissue, body mass, water consumption of animals. p-Hydroxycinnamic diester had satisfactory results, and this product could be useful for diabetes treatment. [Display omitted] •Carnauba wax has promissing pharmacological properties.•P-hydroxycinnamic diesters from carnaúba wax presented hypoglicemic and antioxidant effect.•CG-MS revealed the majoritary presence of p-hidroxycinnamic derivates.