α-Glucosidase and non-enzymatic glycation inhibitory potential of Eugenia dysenterica fruit pulp extracts

α-Glucosidase and non-enzymatic glycation inhibitory potential of Eugenia dysenterica fruit pulp extracts

Considering the nutritional benefits of fruits on human health, this study aimed to screen 11 fruits found in the Brazilian Savanna for glycoside hydrolases inhibitors with antioxidant and anti-glycation properties. Aqueous and ethanol extracts of pulps were used in enzymatic assays to evaluate the...

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Veröffentlicht in:Food bioscience 2020-06, Vol.35, p.100573, Article 100573
Hauptverfasser: Justino, Allisson Benatti, de Moura, Francyelle Rosa Borges, Franco, Rodrigo Rodrigues, Espindola, Foued Salmen
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes mellitus
Eugenia dysenterica
Glycation end-products
Glycoside hydrolases
Polyphenols
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Zusammenfassung:Considering the nutritional benefits of fruits on human health, this study aimed to screen 11 fruits found in the Brazilian Savanna for glycoside hydrolases inhibitors with antioxidant and anti-glycation properties. Aqueous and ethanol extracts of pulps were used in enzymatic assays to evaluate the inhibitory potential against α-amylase and α-glucosidase, as well as antioxidant (2,2-diphenyl-1-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) assays) and anti-glycation (BSA-fructose model) capacities. Ethanol extracts of Campomanesia xanthocarpa, Byrsonima verbascifolia and Eugenia dysenterica had the lowest DPPH IC50 values (0.60 mmol trolox equivalents/g). The extracts of E. dysenterica showed potential to inhibit glycation (IC50 
ISSN:2212-4292
2212-4306
DOI:10.1016/j.fbio.2020.100573