The preventive effect of Xuebijing injection against cytokine storm for severe patients with COVID-19: A prospective randomized controlled trial

COVID-19 is severely affecting countries globally and mortality is high. Xuebijing (XBJ) injection is widely used in the treatment of severe pneumonia and sepsis in China due to its anti-inflammatory effect and immunoregulation. This study investigated whether Xuebijing injection can prevent the cyt...

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Veröffentlicht in:European journal of integrative medicine 2021-02, Vol.42, p.101305-101305, Article 101305
Hauptverfasser: Luo, Zhijian, Chen, Wei, Xiang, Mingqing, Wang, Hua, Xiao, Wei, Xu, Cheng, Li, Yunkui, Min, Jie, Tu, Qiang
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Sprache:eng
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Zusammenfassung:COVID-19 is severely affecting countries globally and mortality is high. Xuebijing (XBJ) injection is widely used in the treatment of severe pneumonia and sepsis in China due to its anti-inflammatory effect and immunoregulation. This study investigated whether Xuebijing injection can prevent the cytokine storm and reduce the mortality from severe COVID-19. This was a randomized, double-blinded trial in which 60 eligible patients were recruited from the First people's Hospital of Jingzhou from February 16 to March 25 in 2020. A total of 57 completed the trial, 3 dropped out. The treatment group received routine medication plus Xuebijing injection while the control group received routine medication plus saline. The secretion of interleukin-6(IL-6), interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α) was suppressed significantly (P 
ISSN:1876-3820
1876-3839
DOI:10.1016/j.eujim.2021.101305