Free radicals and enzymes inhibitory potentials of the traditional medicinal plant Echium angustifolium

Herbal medicine has been useful in the treatment of various diseases and has played a critical role in the discovery of new drugs. This study aimed to investigate the phytoconstituents, antioxidant, antidiabetic and antiobesity activities of the traditional medicinal plant, Echium angustifolium Mill. The constituents of E.angustifolium four solvents fractions were established utilizing conventional analytical methods. Antioxidant, antilipase, anti-glucosidase, and anti-α-amylase activities of E. angustifolium were conducted using DPPH (1,1-diphenyl-2-picrylhydrazyl α), p-nitrophenyl butyrate, P-NPG (4-nitrophenyl β-d-glucopyranoside), and dinitrosalicylic acid procedures, respectively. The methanolic fraction of E. angustifolium displayed inherent antioxidant properties with an IC50 value of 1.95 μg/mL. Moreover, the hexane fraction presented potential α-amylase inhibitory activity with an IC50 value of 92.89 μg/mL. Additionally, the aqueous fraction had the highest anti-lipase activity with an IC50 value of 24.54 μg/mL. It can be concluded that E. angustifolium has high potential for development as an alternative approach for oxidative stress, diabetes, and obesity.