An electrochemical nanosensor for simultaneous quantification of acetaminophen and acyclovir by ND@Dy2O3-IL/CPE

•Synthesis and characterization of ND@Dy2O3 nanocomposite.•Simultaneous quantification of AC and ACV by ND@Dy2O3-IL/CPE.•Obtaining maximum current densities based on response surface methodology.•Advantages of stability, repeatability and reproducibility of the nanosensor.•Good capability of nanosensor for determination of AC and ACV in the human plasma. Current study describes fabrication of a novel voltammetric nanosensor for the synchronize quantification of acetaminophen (AC) and Acyclovir (ACV) by nanodiamond decorated dysprosium oxide and ionic liquid (IL) modified carbon paste electrode (ND@Dy2O3-IL/CPE). Cyclic voltammetry (CV), choronoamperometry, electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV) were utilized to evaluate the modified electrodes. The oxidation peak currents of AC and ACV were increased effectively at the ND@Dy2O3-IL/CPE against bare CPE. Results from response surface methodology (RSM) specified that pH of 4.0 for phosphate buffer solutions (PBS), 0.07 g of ND@Dy2O3 and 0.01 g of IL in the ND@Dy2O3-IL/CPE and 0.04 V of pulse height consequences in the maximum electro-catalytic current. The limit of detection (LOD) and linear dynamics range (LDR) for the simultaneous measurement of AC and ACV were calculated to be 0.031 and 0.103–161.7 for AC and 0.029 μM, 0.097–116.6 μM for ACV, respectively. The catalytic rate constants were measured to be 5.6 × 105 and 4 × 106 cm3 mol−1 s−1 for AC and ACV, respectively. The ND@Dy2O3-IL/CPE displayed worthy stability, repeatability and extraordinary recovery. The practical using of the proposed ND@Dy2O3-IL/CPE was confirmed by quantifying the concentrations of AC and ACV in human serum sample. General schematic of the research is synthesis of ND@Dy2O3 nanocomposite, fabrication of ND@Dy2O3-IL/CPE, optimization of the effecting parameters on the electrochemical response, recording the DPV of this nanosensor for determination of AC and ACV. [Display omitted]