The role of dynamic contrast-enhanced MRI in evaluation of percutaneous transluminal angioplasty outcome in patients with critical limb ischemia

•DCE-MRI is a safe and reproducible technique for evaluation of foot hypoperfusion.•DCE-MRI can be used to estimate PTA outcome in patients with CLI.•Significant restitution of perfusion parameters is found after successful PTA.•There is no significant correlation between ABI and perfusion parameter...

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Veröffentlicht in:European journal of radiology 2020-08, Vol.129, p.109081-109081, Article 109081
Hauptverfasser: Galanakis, Nikolaos, Maris, Thomas G, Kontopodis, Nikolaos, Ioannou, Christos V., Tsetis, Konstantinos, Karantanas, Apostolos, Tsetis, Dimitrios
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Sprache:eng
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Zusammenfassung:•DCE-MRI is a safe and reproducible technique for evaluation of foot hypoperfusion.•DCE-MRI can be used to estimate PTA outcome in patients with CLI.•Significant restitution of perfusion parameters is found after successful PTA.•There is no significant correlation between ABI and perfusion parameters. Imaging modalities such as CTA and MRA provide significant information about the distribution of macrovascular lesions of the limbs in patients with peripheral arterial disease but not for the local microvascular perfusion of the feet. The purpose of this study is to evaluate foot perfusion in patients with critical limb ischemia (CLI) and estimate percutaneous transluminal angioplasty (PTA) results, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Ten patients (6 male, median age 68 years) with CLI were examined. All patients underwent DCE-MRI of the lower limb before and within first month after PTA. Perfusion parameters such as blood flow (BF), Ktrans, Kep were analyzed and applied for statistical comparisons. The studies were also examined by a second observer to determine inter-observer reproducibility. Revascularization was technically successful in all patients and mean ankle brachial index (ABI) increased from 0.37 ± 0.18 to 0.76 ± 0.23, p 
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2020.109081