Role of pyroptosis in cancer and its therapeutic regulation

Pyroptosis is mainly considered a gasdermin-regulated cell death mechanism characterized by cellular lysis and the release of several pro-inflammatory factors. Nowadays, pyroptosis has notably been gained extensive attention from clinicians and researchers. However, current studies report that downregulation of pyroptosis-mediated cell death plays a significant role in developing multiple cancers. Increasing studies also suggest that pyroptosis can impact all stages of carcinogenesis. Inducing pyroptotic cellular death could be a promising therapeutic option for managing and regulating multiple cancers in the near future. Our current review highlights the molecular and morphological features of pyroptosis and its potential roles in various cancers. In addition, we have also highlighted the biological characteristics and significances of GSDMD and GSDME and their critical functions in cancer progression, management and regulation. •Pyroptosis is a gasdermin-mediated cell death.•Cancer is one of the most leading causes of public health issues worldwide.•Pyroptosis contributes to the pathogenesis of cancers.•Some pharmacological agents can be promising therapeutic candidates in treating cancers.•Inducing pyroptosis could be a novel therapeutic option for treating and regulating cancers.