Organophosphate flame retardants and bisphenol A in children's urine in Hong Kong: has the burden been underestimated?

The urine levels of organophosphate flame retardants (PFRs) and bisphenol A (BPA) in kindergarten children (n = 31, 4–6 years old, sampling performed in 2016) in Hong Kong were measured. The detection frequency of the target PFRs, tri(2-chloroethyl)phosphate (TCEP), tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), tris(chloroisopropyl)phosphate (TCIPP), triphenyl phosphate (TPHP) and 2-ethylhexyl diphenyl phosphate (EHDPP) ranged from 52% to 84%. The 95th percentile urinary concentrations of TPHP, TDCIPP, TCIPP, EHDPP and TCEP were 1.70, 0.24, 0.03, 0.05, 0.68 and 0.03 ng/mL, respectively. The median urine level of BPA was 1.69 ng/mL, with a detection frequency of 77%. Due to the lack of metabolism information, two scenarios were used to calculate the estimated daily intake (EDI) of these compounds. Back-calculated EDIs of PFRs using the urinary excretion rates from in vivo animal data (scenario 2) were up to 2.97 μg/kg/d (TDCIPP), which was only a little less than that observed in a sample of American infants, and the reference dose (RfD), meaning that the potential health risk of TDCIPP cannot be ignored. Dust ingestion was suggested to be the major pathway of exposure to PFRs, but when the levels in dust and air particles in kindergartens in Hong Kong were used to predict EDIs, these values were nearly half as much as those predicted from urinary TDCIPP in this study. This suggested that children's PFRs burden may be underestimated when considering only PFR levels in dust or air. There is thus a need for further studies with large-scale surveys and investigation of exposure routes. Urine levels of organophosphate flame retardants (PFRs) and bisphenol A (BPA) of kindergarten children (n = 31, 4–6 years old) in Hong Kong were measured. The 95 percentile urinary concentrations of TPHP, TDCIPP, TCIPP, EHDPP, and TCEP were 1.70, 0.24, 0.03, 0.05, 0.68 and 0.03 ng/mL, respectively. Two scenarios were used to calculate the estimated daily intake (EDI), and the EDI of TDCIPP were up to 2.97 μg/kg/d, which is a little less than those of infants in America, and its reference dose (RfD). The potential health risk of TDCIPP cannot be ignored. Using the levels in dust and air particles in kindergartens in Hong Kong, the predicted EDIs were nearly half as much as those predicted from urinary TDCIPP in the present study. Children's burden of some kind of PFRs might be underestimated when only considering their levels in dust or air. [Display omitted] •PFRs and BPA were