Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation study

Continuous assessment of cerebral autoregulation (CA) using pressure reactivity index (PRx), is a promising tool for individualized management to improve outcome after traumatic brain injury (TBI). However, experience with CA in paediatric TBI (pTBI) is limited to retrospective or single-centre stud...

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Veröffentlicht in:	EClinicalMedicine 2025-03, Vol.81, p.103077, Article 103077
Hauptverfasser:	Agrawal, Shruti, Smith, Claudia, Bogli, Stefan Y., Placek, Michal M., Cabeleira, Manuel, White, Deborah, Daubney, Esther, Young, Adam, Beqiri, Erta, Kayani, Riaz, O'Donnell, Diarmuid, Pathan, Nazima, Watson, Suzanna, Maw, Anna, Ganrett, Matthew, Kanthimathianathan, Hari Krishan, Bangalore, Harish, Sundararajan, Santosh, Subramanian, Gayathri, Raffaj, Dusan, Sarfatti, Avishay, Lampareillo, Simona, Mayer, Anton, Ross, Oliver, Czosnyka, Marek, Hutchinson, Peter J., Smielewski, Peter, Tooke, Carly, Payne, Caroline, Belfield, Holly, Mistry, Amisha, Spencer, Collette, Jennings, Claire, Bunni, Lara, Anderson, Laura, Morgan, Emily, James, Melanie, Beckley, Rebecca, Khatun, Tahnima, Khatun, Hafiza, Nugent, Olivia, Aldridge, Richard, Morgan, Ruth, Morcombe, Julie, Quinton, Martin, Postlethwaite, Catherine, Pond, Jenny, Cutler, Jessica, Oxford, Caitlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cerebral autoregulation Cerebral perfusion pressure (CPP) Paediatric traumatic brain injury Pressure reactivity index (PRx)
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Zusammenfassung:	Continuous assessment of cerebral autoregulation (CA) using pressure reactivity index (PRx), is a promising tool for individualized management to improve outcome after traumatic brain injury (TBI). However, experience with CA in paediatric TBI (pTBI) is limited to retrospective or single-centre studies. Studying Trends of AutoRegulation in Severe Head Injury in Paediatrics (STARSHIP) (clinicalTrials.gov identifier-NCT0688462), was a prospective, multicentre, observational, research database study conducted across 10 identified UK Paediatric Intensive Care Units from 01.07.2018 till 31.04.2024. The main objective was to validate and identify optimal thresholds of PRx associated with outcome (as assessed with Glasgow outcome scale extended for Pediatrics at 12 months) in children (
ISSN:	2589-5370 2589-5370
DOI:	10.1016/j.eclinm.2025.103077