A robust camphor-based colorimetric and fluormetric dual-modal probe with a large Stokes shift for real-time monitoring of endogenous labile Fe2+ in vivo and in vitro

A robust camphor-based colorimetric and fluormetric dual-modal probe with a large Stokes shift for real-time monitoring of endogenous labile Fe2+ in vivo and in vitro

Fe2+ plays a critical role in many physiological processes in the human body. The abnormal level of Fe2+ is implicated in a variety of diseases ranging from anemia to heart failure and even cancer. Herein, a new camphor-derived colorimetric and fluormetric dual-modal probe CCO was constructed for re...

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Veröffentlicht in:Dyes and pigments 2021-10, Vol.194, p.109590, Article 109590
Hauptverfasser: Zhang, Yan, Gong, Shuai, Song, Jie, Li, Mingxin, Qin, Ahui, Gao, Yu, Wang, Zhonglong, Wang, Shifa
Format: Artikel
Sprache:eng
Schlagworte:
Bioimaging
Camphor
Ferroptosis
Fluorescent probe
Labile Fe2
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Zusammenfassung:Fe2+ plays a critical role in many physiological processes in the human body. The abnormal level of Fe2+ is implicated in a variety of diseases ranging from anemia to heart failure and even cancer. Herein, a new camphor-derived colorimetric and fluormetric dual-modal probe CCO was constructed for real-time monitoring and imaging of Fe2+ in vitro and vivo. The probe CCO manifested excellent selectivity, superior sensitivity (LOD = 8.3 nM), large Stokes shift (~208 nm), rapid reaction time (
ISSN:0143-7208
1873-3743
DOI:10.1016/j.dyepig.2021.109590