Effects of garlic powder supplementation on insulin resistance, oxidative stress, and body composition in patients with non-alcoholic fatty liver disease: A randomized controlled clinical trial

•The global prevalence of non-alcoholic fatty liver disease (NAFLD) is nearly 25 %.•Insulin resistance, oxidative stress, and obesity are main causes of NAFLD.•In this clinical trial, Garlic improved insulin resistance and oxidative stress.•Garlic reduced waist circumference without losing weight. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Insulin resistance, oxidative stress, and obesity are major contributors to NAFLD pathogenesis. The effects of garlic powder supplementation on these risk factors in patients with NAFLD was investigated. In this 12-wk, randomized controlled clinical trial, ninety patients with NAFLD were randomly assigned to two groups. The treatment group received four tablets of garlic (each coated tablet contained 400 mg garlic powder) daily and the control group received four tablets of placebo (each coated tablet contained 400 mg starch). A significant decrease was seen in the treatment group compared to the control group in waist circumference (P = 0.001), body fat percent (P