A multifunctional nanocomposite based on Pt-modified black phosphorus nanosheets loading with l-arginine for synergistic gas-sonodynamic cancer therapy

Human health is being seriously harmed by tumors. In order to obtain excellent anti-tumor effects, platinum (Pt) nanozyme-modified black phosphorus (BP) loading with L-Arginine (LArg) (BPPL) is prepared to realize nitric oxide (NO) therapy and sonodynamic therapy (SDT), achieving a synergistic effect to therapy. In this system, BP is utilized as the sonosensitizer. Pt can catalyze the decomposition of hydrogen peroxide (H2O2) to produce oxygen (O2) and relieve the hypoxic environment of tumor tissue. The increase in O2 concentration is conducive to the generation of ROS under ultrasound (US) stimulation. The deposition of precious metals hinders the recombination of some electrons (e) and holes (h+), and further improves the yield of reactive oxygen species (ROS). LArg is employed as the exogenous NO supplementation. Under the stimulation of US and ROS, NO is generated to cause further cell apoptosis. Tests in vitro and in vivo have proved the great potential of the combination of SDT and gas therapy in tumor treatment. [Display omitted] •Ultra-small platinum particles are formed in situ on the surface of black phosphorus.•The effect of sonodynamic therapy is improved through the modification of precious metals.•L-Arginine and black phosphorus achieve the synergistic gas and sonodynamic therapy under ultrasound stimulation.