A novel nanohybrid of gold nanoparticles anchored copper sulfide nanosheets as sensitive sensor for nonenzymatic glucose detection

[Display omitted] •A novel nonenzymatic sensor of Au-CuxS/3DCF was prepared for glucose detection.•The sensor detects glucose with good sensitivity and low LOD of 7.62 μM.•The sensor detects glucose with wide linear detection range of 1.98–976.56 μM.•The sensor exhibited good durability, selectivity as well as excellent stability. In this study, we developed a sensitive glucose sensor by hybridizing abundant gold nanoparticles on surface of copper sulfide nanosheets supported three-dimensional framework. The sensor showed high activity and long-term stability towards glucose oxidation. In this context, is was recognized an adequate sensitivity of 0.059 mA μM−1 cm-2, wide linear detection range of 1.98–976.56 μM, along with low LOD of 7.62 μM. Besides, the sensor also presented high selectivity and good retention of around 85.9% after long-term operation of 1800s. These results may be assumed to the synergistic effects produced by the combination between gold nanoparticles and copper sulfide nanosheets, as well as the formation of hierarchical 3D architecture, which promoted electroactive surface area, charge transfer, electrolyte penetration, and ion diffusion, thereby leading to the enhancement of catalytic activity. Our work may open a new option for developing highly catalytic material for glucose sensor in analytical purposes.