A dominant activating RAC2 variant associated with immunodeficiency and pulmonary disease

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2020-03, Vol.212, p.108248, Article 108248
Hauptverfasser:	Smits, B.M., Lelieveld, P.H.C., Ververs, F.A., Turkenburg, M., de Koning, C., van Dijk, M., Leavis, H.L., Boelens, J.J., Lindemans, C.A., Bloem, A.C., van de Corput, L., van Montfrans, J., Nierkens, S., van Gijn, M.E., Geerke, D.P., Waterham, H.R., Koenderman, L., Boes, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult B-Lymphocytes - immunology Disease Progression Gain of Function Mutation Graft vs Host Disease - drug therapy GTPase-Activating Proteins - metabolism Guanosine Triphosphate - metabolism Hematopoietic Stem Cell Transplantation Heterozygote Humans Immunologic Memory - immunology Immunosuppressive Agents - therapeutic use Infant Lung Diseases - genetics Lung Diseases - immunology Lung Diseases - physiopathology Lung Diseases - surgery Lung Transplantation Lymphopenia - genetics Lymphopenia - immunology Male Molecular Docking Simulation Neutrophils Primary Immunodeficiency Diseases - genetics Primary Immunodeficiency Diseases - immunology Primary Immunodeficiency Diseases - therapy rac GTP-Binding Proteins - genetics rac GTP-Binding Proteins - immunology rac GTP-Binding Proteins - metabolism rac GTP-Binding Proteins - ultrastructure RAC2 GTP-Binding Protein Recurrence Respiratory Tract Infections - immunology T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology
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ISSN:	1521-6616 1521-7035
DOI:	10.1016/j.clim.2019.108248