Wireless power supply near-infrared light drug-loaded microneedle system for the treatment of linear skin wounds

A wirelessly powered near-infrared light drug-loaded microneedle device designed for skin wound healing can achieve synergistic photo-drug therapy. The device adheres to the skin, capable of penetrating the stratum corneum to achieve precise targeted drug delivery, while effectively delivering near-infrared light from the skin surface to deeper tissues. [Display omitted] •A new structure of a phototherapy-drug combined microneedle system has been proposed.•The application of programmable wireless power supply light sources makes treatment more convenient.•A new scheme for treating skin wounds has been proposed. The healing of linear skin wounds is a complex biological process, and traditional treatment methods have certain limitations. This study proposes a wireless power supply near-infrared light drug-loaded microneedle system (NIR-LED-NG-R1-MN), which utilizes microneedles (MNs) to achieve targeted delivery of the active component of traditional Chinese medicine, Notoginsenoside R1 (NG-R1), and combines the biological regulatory effect of near-infrared light (NIR) to achieve efficient synergistic treatment for linear skin wounds. Experimental results show that the device can significantly promote the wound closure rate and reduce the levels of inflammatory factors and the risk of scar formation. By comparing the wound repair conditions of different treatment groups, it was found that the group treated with the NIR-LED-NG-R1-MN patch for NG-R1 and NIR synergistic treatment (MN@NG-R1@LED group) showed superior wound repair effects compared to other groups, thus confirming the synergistic therapeutic advantages of NG-R1 and NIR in skin wound healing. In addition, the application of wireless power supply technology used in this system eliminates the dependence on external power sources, enhancing the convenience of treatment. This study clearly demonstrates that the NIR-LED-NG-R1-MN has the potential to become a new clinical method for the treatment of linear skin wound healing.