Strain-insensitive bioelectronics

•Various geometric structures to obtain strain-insensitivity are outlined.•Stress engineering methods for realizing strain insensitivity are discussed.•The principles for achieving strain insensitivity in material design are summarized.•A overview about representative strain-insensitive bioelectronics is presented. In recent years, the rapid advancement of wearable multifunctional bioelectronics has expanded the horizons of smart biomedical and healthcare applications. However, there is a pressing need for the development of multifunctional strain-insensitive bioelectronics due to the susceptibility of bioelectronics attached to the skin or tissues, which can lead to operational challenges and signal interference. Therefore, the pressing need to progress wearable health monitoring electronics hinges on the advancement of multifunctional strain-insensitive bioelectronics, with the goal of mitigating signal interference caused by deformations. This review offers a comprehensive exploration of the technologies and applications involved in achieving strain insensitivity in bioelectronics. First, the methods to mitigate signal interference resulting from deformation are discussed, encompassing geometric structural design, stress engineering, and material selection. Subsequently, we delve into specific applications that leverage these approaches in the realm of bioelectronic devices and beyond. Finally, a concise summary and discuss about the prospects and obstacles in this dynamic field are provided. This article serves as an effective solution to address the current demand for multifunctional strain-insensitive bioelectronics and offers inspiration for future endeavors in wearable electronics, health monitoring, and implantable medical devices.