Piezocatalytic strategy facilitates diabetic bone regeneration through high-performance anti-oxidative recycling

The piezocatalytic nanocomposite membrane is fabricated by GO incorporation and PDA self-assembly. In response to external ultrasound exposure, high-performance electric output can be achieved. Composite membranes are implanted onto the surface of cranial bone defects, followed by ultrasound-mediated electric output for piezocatalytic therapy. In detail, piezoelectric output under ultrasound exposure triggers directional transport and emission of electron within built-in electric field, resulting in efficient recycling of redox activity from quinone group to phenolic group under diabetes-associated microenvironment full of oxidative products. This piezocatalytic strategy accomplishes persistent and long-term anti-oxidative potential for diabetic bone regeneration. Under the anti-oxidative treatment of piezocatalytic strategy, stagnated osteogenic differentiation of BMSCs and anti-inflammatory M2 macrophage polarization in hyperglycemic microenvironment have all been significantly promoted and enhanced, resulting in optimized diabetic bone repair. [Display omitted] •Composite membranes exhibit excellent piezocatalytic potential.•Piezocatalytic effect performs efficient recycling of anti-oxidative reaction.•Piezocatalytic strategy executes high-performance ROS scavenging.•Piezocatalytic strategy significantly accelerates diabetic bone regeneration. Anti-oxidative therapy for resistance of oxidative stress-induced damage has attracted substantial attention for bone regeneration under diabetic conditions. However, most anti-oxidants suffer from low efficiency due to their one-off reaction with oxidative products and rapid loss of activity. Herein, the piezoelectric nanocomposite with built-in electric field was fabricated as a cyclic anti-oxidative device for improved reactive oxygen species (ROS) scavenging and pro-osteogenic outcome. Under ultrasound (US) irradiation, the polydopamine (PDA) -functionalized generator with piezocatalytic effect exhibits high-performance recycling of redox catalytic reaction via continuous electron supplementation for cyclic group switch from quinone to phenol. The piezocatalytic method substantially boosts ROS elimination and reverses inflammatory status, contributing to strengthened osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and M2 polarization of macrophages. In vivo results further validated superior bone healing in rats with diabetes mellitus (DM). Our study therefore provides fundamental insi