Super disintegrating oromucosal nanofiber patch of zolmitriptan for rapid delivery and efficient brain targeting

Super disintegrating oromucosal nanofiber patch of zolmitriptan for rapid delivery and efficient brain targeting

[Display omitted] •The quality by design helps to understand optimization and saves time and raw materials for formulation development.•The nanofiber patch of zolmitriptan disintegrates rapidly and releases 80% of the drug in 2-folds). The drug targeting these brain regions likely resulted from rapi...

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Veröffentlicht in:Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2023-05, Vol.463, p.142481, Article 142481
Hauptverfasser: Shafi, Hasham, Rashid, Rumaisa, Rather, Sami-ullah, Siva Reddy, D.V., Azmi, Lubna, Abdal-hay, Abdalla, Alrokayan, Salman H., Khan, Haseeb A, Ahmad Khan, Nisar, Sheikh, Faheem A.
Format: Artikel
Sprache:eng
Schlagworte:
Brain targeting
Electrospinning
Nanofibers
Rapid disintegration
Zolmitriptan
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Beschreibung
Zusammenfassung:[Display omitted] •The quality by design helps to understand optimization and saves time and raw materials for formulation development.•The nanofiber patch of zolmitriptan disintegrates rapidly and releases 80% of the drug in 2-folds). The drug targeting these brain regions likely resulted from rapid dissolution, enhanced permeation, amo
ISSN:1385-8947
1873-3212
DOI:10.1016/j.cej.2023.142481