Design, synthesis and anticancer evaluation of chalcone incorporated 1,2,4-thiadiazole-oxazolo[4,5-b]pyridine derivatives

A novel series of chalcones incorporated 1,2,4-thiadiazole-oxazolo [4,5-b]pyridines (10a-j) have been designed, synthesized and their chemical structures were characterized by 1HNMR, 13CNMR and Mass spectral analysis. Further, all these compounds were screened for their anticancer activity against four human cancer cell lines including MCF-7 (breast carcinoma), A549 (lung carcinoma), Colo-205 (colon carcinoma) and A2780 (ovarian carcinoma) by using the MTT method. These screened compounds exhibited more potent anticancer activity with IC50 ranging from 0.013 ± 0.0013 to 12.45 ± 6.57 μM, in comparison to the reference drug, etoposide with IC50 values range 0.13 ± 0.017 to 3.08 ± 0.135 μM. Among all synthesized compounds 10b, 10c, 10d, 10e, 10g, 10h and 10i displayed more potent activity towards all four screened cancer cells.