Total synthesis of the proposed structure of Pandangolide 1

Total synthesis of the proposed structure of Pandangolide 1

A total synthesis of a proposed structure of Pandangolide 1 is described. The key features of the synthesis include Grignard reaction, Asymmetric dihydroxylation, Yamaguchi macrolactonization and RCM. Cost-effective and readily available precursors like (R)-glyceraldehyde is used as the starting mat...

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Veröffentlicht in:Chemical Data Collections 2023-04, Vol.44, p.101000, Article 101000
Hauptverfasser: Nimmareddy, Rajashekar Reddy, Gandham, Himabindu, Desireddi, Janardana Reddi, Dende, Satheesh Kumar, Rapolu, Thirupathi, Murahari, Kiran Kumar, Leleti, Krishnakanth Reddy
Format: Artikel
Sprache:eng
Schlagworte:
Grignard reaction
Pandangolide 1
Sharpless asymmetric dihydroxylation and AD-mix-β
Swern oxidation
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Zusammenfassung:A total synthesis of a proposed structure of Pandangolide 1 is described. The key features of the synthesis include Grignard reaction, Asymmetric dihydroxylation, Yamaguchi macrolactonization and RCM. Cost-effective and readily available precursors like (R)-glyceraldehyde is used as the starting material for the synthesis. [Display omitted]
ISSN:2405-8300
2405-8300
DOI:10.1016/j.cdc.2023.101000