Novel Areca Nut extract mediated preparation of TiO2 nanoparticles and its catalytic synthesis of 3, 3′- (phenyl methylene) bis-(4-hydroxy-2H-chromen-2-one) derivatives

•Preparation of TiO2 nanoparticles by Novel Areca nut extract and characterized by using UV-Vis, FT-IR, XRD and SEM with EDAX analyses.•Synthesized 3, 3′- (phenylmethylene) bis-(4-hydroxy-2H-chromen-2-one) derivatives by using biogenic TiO2 nanoparticles and synthesized compounds were characterized by different spectral techniques like FT-IR, 1H NMR, 13C NMR and LCMS studies.•DFT studies of synthesized compounds showed that the HOMO and LUMO plays significant role in knowing the structure-activity relationship. Moreover, electrostatic potential maps of synthesized compounds have shown behavioral reactive sites.•All the studied compounds exhibited good antioxidant, antimicrobial and anti-tuberculosis activities.•Employed biogenic TiO2 catalyst exhibited best recyclability upto fifth cycle. The present study describes the preparation of Areca Nut extract mediated TiO2 and its catalytic application for the synthesis of 3, 3′-(phenyl methylene) bis-(4-hydroxy-2H-chromen-2-one) derivatives by conventional multicomponent reaction. The synthesized compounds have been characterized by FT-IR, 1H NMR, 13C NMR and mass spectrometric techniques. Computational studies have been carried out to interpret the structural activity relationship of the synthesized compounds using the B3LYP program at 6e311þþ (d, p) basis set. Additionally, the synthesized compounds were screened for their efficacy towards the antioxidant, antimicrobial, and antituberculosis properties. Further, the recyclability of the employed catalyst has been studied. [Display omitted]