Elevated glucocorticoids during gestation suggest sex-specific effects on offspring telomere lengths in a wild lizard

Elevated glucocorticoids during gestation suggest sex-specific effects on offspring telomere lengths in a wild lizard

The effects of maternal glucocorticoids (e.g. corticosterone, CORT) on offspring interest biologists due to increasing environmental perturbations. While little is known about the impact of maternal CORT on offspring fitness, it may modulate telomere length and compromise offspring health. Here, we...

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Veröffentlicht in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2021-07, Vol.257, p.110971, Article 110971
Hauptverfasser: Ensminger, David C., Siegel, Sue R., Owen, Dustin A.S., Sheriff, Michael J., Langkilde, Tracy
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal Cortex Hormones - pharmacology
Animals
Cellular Senescence
Corticosterone - metabolism
DNA - analysis
DNA - metabolism
Female
Glucocorticoids - metabolism
Lizards - physiology
Maternal stress effects
Phenotype
Phenotypic alterations
Pregnancy
Pregnancy, Animal
Prenatal Exposure Delayed Effects
Prenatal stress
Real-Time Polymerase Chain Reaction
Sceloporus undulatus
Stress response
Stress, Physiological
Telomere - ultrastructure
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Zusammenfassung:The effects of maternal glucocorticoids (e.g. corticosterone, CORT) on offspring interest biologists due to increasing environmental perturbations. While little is known about the impact of maternal CORT on offspring fitness, it may modulate telomere length and compromise offspring health. Here, we use a modified real-time quantitative PCR assay to assess telomere length using small DNA quantities (
ISSN:1095-6433
1531-4332
DOI:10.1016/j.cbpa.2021.110971