Chemical constituents of Euphorbia peplus

Phytochemical investigation of the whole plant of Euphorbia peplus Linn. led to the isolation of previously uncharacterized jatrophane type diterpenoid euphopepluanone L (1), along with seven known compounds, including three diterpenes (2–4), three bisnorsesquiterpenes (5–7), and a monoterpene (8). Their chemical structures were established based on extensive spectroscopic analysis. Compounds 3 (20-deoxyingenol) and 5–8 were firstly isolated from E. peplus, while PBI 345 (5) reported from the genus for the first time. Furthermore, the chemotaxonomic significance of the isolates was discussed. •Eight compounds (1–8) were isolated from Euphorbia peplus.•The structure of a previously undescribed jatrophane type diterpenoid (1) was established.•It is the first report of isolation of compound 5 from the genus Euphorbia.•Chemotaxonomic significance of these compounds was described.