The combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity

[Display omitted] •CF-Sesamol was designed and synthesized, which showed a significant activity of reducing TG and TC.•CF-Sesamol displayed potent antioxidant, anti-inflammatory and hepatoprotective effects.•The hepatoprotective mechanism was through the Nrf2/NF-κB signaling pathway. Oxidative stress and inflammation have been considered the main factors in the liver injury of clofibrate (CF). To obtain a novel antihyperlipidemic agent with antioxidant, anti-inflammation and hepatoprotection, the combination of sesamol and clofibric acid moieties was performed and achieved sesamol-clofibrate (CF-Sesamol). CF-Sesamol showed significant hypolipidemia effects in hyperlipidemia mice induced by Triton WR 1339, reducing TG by 38.8% (P