Investigations of antiproliferative and antioxidant activity of β-lactam morpholino-1,3,5-triazine hybrids

[Display omitted] This article reports for the first time the synthesis of some novel β-lactam morpholino-1,3,5-triazine hybrids by a [2+2]-cycloaddition reaction of imines 7a–c, 9a–c and 11 with ketenes derived from substituted acetic acids. The reaction was totally diastereoselective, leading excl...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2020-04, Vol.28 (8), p.115408, Article 115408
Hauptverfasser: Ranjbari, Somayeh, Behzadi, Maryam, Sepehri, Saghi, Dadkhah Aseman, Marzieh, Jarrahpour, Aliasghar, Mohkam, Milad, Ghasemi, Younes, Reza Akbarizadeh, Amin, Kianpour, Sedigheh, Atioğlu, Zeliha, Özdemir, Namık, Akkurt, Mehmet, Masoud Nabavizadeh, S., Turos, Edward
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Sprache:eng
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Zusammenfassung:[Display omitted] This article reports for the first time the synthesis of some novel β-lactam morpholino-1,3,5-triazine hybrids by a [2+2]-cycloaddition reaction of imines 7a–c, 9a–c and 11 with ketenes derived from substituted acetic acids. The reaction was totally diastereoselective, leading exclusively to the formation of cis-β-lactams 8a–l, 10a–f and 12a–c. The synthesized compounds were tested for activity towards SW1116, MCF-7 and HepG2 cancer cell lines and non-cancerous HEK-293 cell line by MTT assay. None of the compounds exert an observable effect on HepG2, MCF-7 and HEK-293 cells, but compounds 7b, 8f, 8g, 8l, 10c, and 10e exhibited excellent growth inhibitory activity (IC50  7b > 8f > 8g. Collectively, the in vitro capabilities of some of these morpholino-triazine imines and β-lactams suggest possible applications to development of new antioxidants and DNA binding therapeutics.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2020.115408