PRELIMINARY DATA ON THE EFFECTS OF PHOTOBIOMODULATION ON TISSUE REPAIR OF BURNING INJURIES: A RANDOMIZED, CONTROLLED, DOUBLE-BLINDED CLINICAL TRIAL

Burning is a tissue injury that can be treated through photobiomodulation, which promotes tissue repair by activating physiological cascades that induce the synthesis of RNA and DNA, increasing the production of new cells. LEDtherapy is a type of phototherapeutic resource that uses photobiomodulation, this resource provides a cheaper treatment, easy to apply with less time when compared to LASERtherapy, this is due to the characteristics of LED light. However, there is a scientific gap, as the studies that have been developed in recent years report the effects of LASER in animal models or in vitro, little is known about the real effect of the treatment of burns with LED in human beings, thinking about it, the idea arose. hypothesis of what is the effect of this resource in human model. To compare the effect of red LED photobiomodulation, infrared LED and sham therapy on the rate of re-epithelialization, presence of pain, pruritus, skin temperature, healing quality and scar mobility among individuals with second-degree burns. This is a double-blind randomized controlled clinical trial. 11 burn injuries were treated, divided into 3 groups: Red Led Group (n = 2), Infrared LED Group (n = 5), and Sham Group (n = 4), the group's stimulation by LED an application of 7J/cm² per point, in the Shan group, the application was mimicked. The presence of pain, itching, skin temperature and wound size were evaluated daily until healing, and at the end of healing, the mobility and quality of the scar were evaluated. Data were analyzed using descriptive statistics, re-epithelialization rate, skin temperature and scar mobility, ANOVA was performed for repeated measures, by Bonferroni post-hoc. One-way anova and for Kruskall wallis scar quality considering a significance level of P ≤ 0.05. There was no statistical difference for the outcome pain, pruritus, rate of re-epithelialization and scar mobility and quality between the groups. However, it is possible to observe a clinical improvement in rate of re-epithelialization, pain and itching in the stimulation groups when compared to the shan. It is necessary to be careful about the inferences made regarding the results of this research due to the low statistical power, however, it is possible to observe a clinical improvement in the volunteers who were treated with led therapy, the re-epithelialization rate and pain resolution and pruritus in the initial 48 hours. The development of studies like this one can answer doubts abo