Recent advances in the development of electrochemical aptasensors for detection of heavy metals in food

Heavy metal contamination in environment and food has attracted intensive attention from the public since it poses serious threats to ecological system and human health. Traditional detection methods for heavy metals such as atomic absorption spectrometry have a fairly low detection limit, but the methods have many limitations and disadvantages. Therefore, it is of significance to develop a rapid technology for real-time and online detection of heavy metals. The electrochemical aptasensor-based technology is promising in the detection of heavy metals with advantages of high sensitivity, specificity, and accuracy. Although its development is rapid, more researches should be carried out before this technology can be used for on-site detection. In this review, the origin, basic principles and development of electrochemical aptasensors are introduced. The applications of nanomaterials and electrochemical aptasensors for the detection of heavy metals (mainly mercury, lead, cadmium, and arsenic) are summarized. The research and application tendency of electrochemical aptasensors for detection of heavy metals are prospected. •New aptamers developed for heavy metals detection in food over the past five years are described.•New methods for rapid detection with their advantages and disadvantages are reviewed.•Various strategies for designing highly sensitive electrochemical aptasensors are proposed.•Application of nanomaterials and electron mediators in electrochemical biosensors is discussed.