Myrianthus libericus: Possible mechanisms of hypoglycaemic action and in silico prediction of pharmacokinetics and toxicity profile of its bioactive metabolite, friedelan-3-one

Myrianthus libericus: Possible mechanisms of hypoglycaemic action and in silico prediction of pharmacokinetics and toxicity profile of its bioactive metabolite, friedelan-3-one

The hypoglycaemic and anti-hyperlipidaemic effects of the 70% ethanol stem bark extract of Myrianthus libericus (MLB), used traditionally in the management of diabetes in Ghana, was evaluated in this study using streptozotocin (45 mg/kg)-induced diabetic rats. In vitro hypoglycaemic activities of th...

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Veröffentlicht in:Biomedicine & pharmacotherapy 2021-05, Vol.137, p.111379, Article 111379
Hauptverfasser: Harley, Benjamin Kingsley, Amponsah, Isaac Kingsley, Ben, Inemesit Okon, Adongo, Donatus Wewura, Mireku-Gyimah, Nana Ama, Baah, Michael Kwesi, Mensah, Abraham Yeboah, Fleischer, Theophilus Christian
Format: Artikel
Sprache:eng
Schlagworte:
C2C12 cells
Friedelan-3-one
Glucose uptake
Hypoglycaemic effect
Myrianthus libericus
α-amylase inhibition
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Zusammenfassung:The hypoglycaemic and anti-hyperlipidaemic effects of the 70% ethanol stem bark extract of Myrianthus libericus (MLB), used traditionally in the management of diabetes in Ghana, was evaluated in this study using streptozotocin (45 mg/kg)-induced diabetic rats. In vitro hypoglycaemic activities of the extract and one of its principal compounds, friedelan-3-one were then investigated using α-amylase inhibitory and glucose uptake assay in C2C12 myotubes. In silico analysis of the pharmacokinetic and toxicity properties of the compound was also performed. MLB significantly (p 
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2021.111379