Nrf2 a molecular therapeutic target for Astaxanthin

Astaxanthin (ATX) is a red pigment carotenoid present in shrimp, salmon, crab, and asteroidean. Several studies have corroborated the anti-oxidant efficacy of ATX. In addition, ATX has anti-inflammatory, anti-apoptotic and anti-proliferative properties. In the present review, we discuss the role of...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-05, Vol.137, p.111374, Article 111374
Hauptverfasser:	Kohandel, Zeynab, Farkhondeh, Tahereh, Aschner, Michael, Samarghandian, Saeed
Format:	Artikel
Sprache:	eng
Schlagworte:	Astaxanthin Inflammation Nrf2 Oxidative stress
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Zusammenfassung:	Astaxanthin (ATX) is a red pigment carotenoid present in shrimp, salmon, crab, and asteroidean. Several studies have corroborated the anti-oxidant efficacy of ATX. In addition, ATX has anti-inflammatory, anti-apoptotic and anti-proliferative properties. In the present review, we discuss the role of Nrf2 in mediating the anti-cancer, anti-aging, neuroprotective, lung-protective, skin-protective, cardioprotective, hepatoprotective, anti-diabetic and muscloprotective effects of ATX.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2021.111374