A look into the link between centrosome amplification and breast cancer

[Display omitted] •Centrosome amplification mostly occurs in cancer cells with series of cellular protein dysfunction.•Centrosome amplification is closely related to poor prognosis of breast cancer patients.•Mutations in centrosomal genes and activated Wnt signaling induce centrosome amplification.•Targeting centrosome amplification provides candidates for curative treatments for breast cancer patients. Centrosome amplification (CA) is a common feature of human tumors, but it is not clear whether this is a cause or a consequence of cancer. The centrosome amplification observed in tumor cells may be explained by a series of events, such as failure of cell division, dysregulation of centrosome cycle checkpoints, and de novo centriole biogenesis disorder. The formation and progression of breast cancer are characterized by genomic abnormality. The centrosomes in breast cancer cells show characteristic structural aberrations, caused by centrosome amplification, which include: an increase in the number and volume of centrosomes, excessive increase of pericentriolar material (PCM), inappropriate phosphorylation of centrosomal molecular, and centrosome clustering formation induced by the dysregulation of important genes. The mechanism of intracellular centrosome amplification, the impact of which on breast cancer and the latest breast cancer target treatment options for centrosome amplification are exhaustively elaborated in this review.