Ketogenic diet improves and restores redox status and biochemical indices in monosodium glutamate-induced rat testicular toxicity

[Display omitted] This study investigated the effect of ketogenic diet on monosodium glutamate (MSG)-induced testicular dysfunction. Forty-six male rats (180 ± 40 g) were grouped into two groups (23 rats each); control group and MSG-induced group (4 mg/kg bw) for 28 days. At the 29th day, 5 rats fro...

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Veröffentlicht in:Biomedicine & pharmacotherapy 2020-07, Vol.127, p.110227, Article 110227
Hauptverfasser: Kayode, Omowumi T., Rotimi, Damilare E., Olaolu, Tomilola D., Adeyemi, Oluyomi Stephen
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Sprache:eng
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Zusammenfassung:[Display omitted] This study investigated the effect of ketogenic diet on monosodium glutamate (MSG)-induced testicular dysfunction. Forty-six male rats (180 ± 40 g) were grouped into two groups (23 rats each); control group and MSG-induced group (4 mg/kg bw) for 28 days. At the 29th day, 5 rats from both group were sacrificed to establish testicular dysfunction. The remaining animals from the control group was further divided into three sub-groups and treated for 42 days; untreated group, ketogenic diet only and curcumin only as the standard drug (150 mg/kg bw). In the pre-treatment, the administration of MSG resulted in a significant (p 
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2020.110227