Long-term thionamide antithyroid treatment of Graves' disease

Thionamide antithyroid drugs (ATD) are the treatment of choice for Graves’ hyperthyroidism. The major drawback of ATD treatment for 1–2 years is the relapse of hyperthyroidism in about 50% of patients. Recently, it has been shown that ATD treatment for more than five years is accompanied by long-term remission in majority of patients without additional major side effects in both adults and children. Compared to radioactive iodine therapy, long-term ATD results in more favorable outcomes. This review summarizes the evidence on long-term ATD therapy regarding the remission rate of hyperthyroidism, efficacy and safety, indications and mode of therapy in patients with hyperthyroidism.