Evaluation of antioxidant, anticancer, antibacterial and antibiofilm potency of panchagavya – A traditional medicine

Panchagavya was successfully prepared using five individual indigenous cow products using fermentation technology. The prepared panchagavya was subjected to standard biochemical procedures, GCMS, and FTIR analysis that revealed the presence of medicinally important compounds. Furthermore, the DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (ferric-reducing antioxidant power) assays reveals that the panchagavya has better antioxidant activity. Moreover, they compressed the potent cytotoxic effect on MDA-MB-231 (a breast cancer cell line). The antibacterial and antibiofilm activity evidenced that the panchagavya obstructed the growth of bacterial biofilm such as Gram-positive E. faecalis, L. monocytogenes, B. subtilis, and Gram-negative P. aeruginosa, S. sonnei, and P. vulgaris. Thereupon, the panchagavya can be brought into the field of biomedical and pharmaceutical applications. [Display omitted] •Panchagavya has been prepared using individual components of indigenous cow.•Panchagavya has plenty of medicinally important biochemical compounds.•Panchagavya has better antioxidant activity against DPPH, and FRAP reagent.•Panchagavya efficiently reduce the viability of MBA-MB-231.•Panchagavya has antibacterial and antibiofilm activity against pathogenic bacteria.